Comfort Inn

Get ready for your next grand expedition with us at our Comfort Inn^® Sioux City South hotel. Many people come to the area to learn about America’s first epic road trip in Sioux City at the Lewis and Clark Interpretive Center and you can, too. Of course, we want you to rest easy knowing your accommodations are much more enjoyable than those of those early explorers. Learn about the history and culture of Sioux City with the convenience of a relaxing environment to get a great night’s rest.

Shop at the nearby Southern Hills Mall or take in an event at the Tyson Events Center. Located off Interstate 29, our hotel is easily accessible from other major cities like Omaha, Nebraska and Sioux Falls, South Dakota. Sioux Gateway Airport is just an 8-minute drive from your cozy guestroom, putting our hotel in the perfect spot for any traveler passing through the area. Enjoy your time in Sioux City with us in our pet-friendly rooms. With premium bedding, a refreshing indoor heated pool and hearty and healthy breakfast options, you’re bound to have a great start to the day. Stay connected with our fast and free WiFi and enjoy your room’s separate work area, so you can get stuff done.